A CONVENIENT SYNTHETIC ROUTE TO N-ARYL AND N-ALKYLAMINO(ALKYL) PHOSPHONATES AND PHOSPHINE OXIDES

A variety of phosphorylated N-aryl and N-alkyl N-formyl and N-tert-but oxycarbonylaminomethyl derivatives have been efficiently prepared by t reatment of the corresponding chloromethyl derivatives with a trialkyl phosphite or an alkyl diphenylphosphinite. These bifunctional compoun ds may be deprotonated with LDA and further submitted to electrophilic substitution. An acidic treatment of the resulting compounds gives ri se to a range of N-aryl and N-alkylamino(alkyl) phosphonates and phosp hine oxides.