Sg. Pyne et al., EXO-DIASTEREOSELECTIVE 1,3-DIPOLAR CYCLOADDITIONS OF AZOMETHINE YLIDES TO 2R)-3-BENZOYL-4-METHYLENE-2-PHENYLOXAZOLIDIN-5-ONE, Tetrahedron letters, 36(14), 1995, pp. 2511-2514
Exo-diastereoselective 1,3-dipolar cycloadditions of azomethine ylides
derived from alpha-amino acid esters to (2R)-3-Benzoyl-4-methylene-2-
phenyloxazolidin (1) are reported. The cycloaddition products are conv
eniently converted to polyfunctional prolines in high enantiomeric pur
ity.