R. Aravboger et al., PORTAL-VEIN THROMBOSIS CAUSED BY PROTEIN-C AND PROTEIN-S DEFICIENCY ASSOCIATED WITH CYTOMEGALOVIRUS-INFECTION, The Journal of pediatrics, 126(4), 1995, pp. 586-588
A 4-month-old girl who was examined because of splenomegaly had portal
vein thrombosis, which apparently resulted from a combination of cyto
megalovirus infection and deficiency of both protein S and protein C.
The cytomegalovirus infection, by damaging endothelial cells, may have
triggered a cascade of events that was ultimately expressed as portal
vein thrombosis resulting from deficiency of proteins S and C.