G. Chiappetta et al., THE EXPRESSION OF THE HIGH-MOBILITY GROUP HMGI (Y) PROTEINS CORRELATES WITH THE MALIGNANT PHENOTYPE OF HUMAN THYROID NEOPLASIAS, Oncogene, 10(7), 1995, pp. 1307-1314
High Mobility Group I(HMGI) proteins are nuclear proteins involved in
the regulation of chromatin structure and function, Elevated expressio
n of the HMGI proteins (HMGI, HMGY and HMGI-C) has been correlated wit
h the presence of a highly malignant phenotype in epithelial and fibro
blastic rat thyroid cells, and in several experimental carcinomas, Her
e, we demonstrate that HMGI and HMGY proteins are expressed in human t
hyroid carcinomas and thyroid carcinoma cell lines, but not in adenoma
s, goiters, normal thyroid tissues and cells, These results indicate a
correlation between HMGI and HMGY expression and the malignant phenot
ype of thyroid neoplasias, suggesting that these proteins may be used
as markers in thyroid cancer.