THE INFLUENCE OF KETANSERIN OR URAPIDIL ON HEMODYNAMICS, STRESS-RESPONSE AND KIDNEY-FUNCTION DURING OPERATIONS FOR MYOCARDIAL REVASCULARIZATION

The study was performed to investigate the different effects of ketans erin and urapidil an haemodynamics, kidney function and plasma catecho lamine and aldosterone levels. Forty male patients scheduled for myoca rdial revascularisation were assigned at random to two groups: group K received ketanserin, group U received urapidil. Anaesthesia consisted of fentanyl, flunitrazepam and pancuronium. Haemodynamic variables we re evaluated at eight predefined time points of the operation. Creatin ine and free-water clearance as well as plasma levels of adrenaline, n oradrenaline and aldosterone were measured in three different periods of the operation. While the groups showed no clinically relevant diffe rences in the haemodynamic variables and the hormone plasma concentrat ions, the creatinine clearance in group K was slightly increased in th e period after cardiopulmonary bypass. Both ketanserin and urapidil pr evented hypertension even in the presence of elevated catecholamine pl asma levels during and after cardiopulmonary bypass.