A. Petry et al., THE INFLUENCE OF KETANSERIN OR URAPIDIL ON HEMODYNAMICS, STRESS-RESPONSE AND KIDNEY-FUNCTION DURING OPERATIONS FOR MYOCARDIAL REVASCULARIZATION, Anaesthesia, 50(4), 1995, pp. 312-316
The study was performed to investigate the different effects of ketans
erin and urapidil an haemodynamics, kidney function and plasma catecho
lamine and aldosterone levels. Forty male patients scheduled for myoca
rdial revascularisation were assigned at random to two groups: group K
received ketanserin, group U received urapidil. Anaesthesia consisted
of fentanyl, flunitrazepam and pancuronium. Haemodynamic variables we
re evaluated at eight predefined time points of the operation. Creatin
ine and free-water clearance as well as plasma levels of adrenaline, n
oradrenaline and aldosterone were measured in three different periods
of the operation. While the groups showed no clinically relevant diffe
rences in the haemodynamic variables and the hormone plasma concentrat
ions, the creatinine clearance in group K was slightly increased in th
e period after cardiopulmonary bypass. Both ketanserin and urapidil pr
evented hypertension even in the presence of elevated catecholamine pl
asma levels during and after cardiopulmonary bypass.