THE EFFECT OF AGING ON THE TRANSARTERIAL WALL OXYGEN GRADIENT

Atherosclerosis is associated with aging based on numerous epidemiolog ic studies, whereas arterial wall hypoxia has been associated with oth er risk factors for atherosclerosis. We studied the effect of age on t he transarterial wall oxygen gradient in the rat using an oxygen micro electrode. A decrease in oxygen tension in the outer 35% of the artery wall was noted in 36- to 40-week-old rats when compared to 3- to 4-we ek-old rats. These findings were noted despite no difference in arteri al blood oxygen tension between the two groups and prior to any histol ogic evidence of atherosclerotic lesion formation. Our observations su ggest that aging decreases the delivery of oxygen to the outer artery wall.