We explored the potential of the picosecond Nd:YLF laser to perform go
nioscopic ab interno sclerostomy in human cadaver eyes. Full-thickness
sclerostomies were created in 12 such eyes and confirmed by external
scleral and histopathologic examination. Optimum parameters for succes
sful completion of a sclerostomy were: a rectangular pattern of 0.3 mm
by 0.3 mm, a repetition rate of 1000 pulses per second, an energy-per
-pulse of 400 mJ, and a spot separation between 10 and 50 mum, with no
focal offset. The Nd:YLF laser reliably created successful gonioscopi
c sclerostomies with minimal adjacent thermal damage in human cadaver
eyes.