PERITONEAL PAPILLARY SEROUS CARCINOMA ARISING IN AN INFERTILE WOMAN DURING OVULATION-INDUCTION THERAPY - IMMUNOHISTOCHEMICAL EXPRESSION OF LH HCG RECEPTORS

A case of peritoneal papillary serous carcinoma arising in an infertil e patient during ovulation-induction therapy is presented. A 34-year-o ld woman with past history of ovulation-induction therapy for infertil ity again received fertility drugs. During the use of gonadotropic hor mones, massive ascites developed and an exploratory laparotomy reveale d serous papillary carcinoma on the surface of bilateral ovaries, pelv ic peritoneum, and omentum. Immunohistochemical analysis showed the tu mor cells to be positive for luteinizing hormone/human chorionic gonad otropin receptors and negative for sex steroid receptors. A possible r elationship between the use of gonadotropic hormones and cancer develo pment is discussed. (C) 1995 Academic Press, Inc.