2,3-BUTANEDIONE MONOXIME (BDM) INCREASES INITIAL YIELDS AND IMPROVES LONG-TERM SURVIVAL OF ISOLATED CARDIAC MYOCYTES

Authors
KIVISTO T MAKIRANTA M OIKARINEN EL KARHU S WECKSTROM M SELLIN LC
Citation
T. Kivisto et al., 2,3-BUTANEDIONE MONOXIME (BDM) INCREASES INITIAL YIELDS AND IMPROVES LONG-TERM SURVIVAL OF ISOLATED CARDIAC MYOCYTES, Japanese Journal of Physiology, 45(1), 1995, pp. 203-210
Citations number
23
Categorie Soggetti
Physiology
Journal title
Japanese Journal of Physiology → ACNP
ISSN journal
0021521X
Volume
45
Issue
1
Year of publication
1995
Pages
203 - 210
Database
ISI
SICI code
0021-521X(1995)45:1<203:2M(IIY>2.0.ZU;2-O
Abstract
When BDM is added to the perfusion solutions used during the preparati on of single, enzymatically dispersed mammalian cardiomyocytes, higher yields of calcium-tolerant cells are obtained. As the principal compo nent of a storage solution, BDM also improves the survival of myocytes maintained in cold storage. These data support the hypothesis that BD M can act as a cardioprotective agent under certain conditions.