Gf. Palmieri et al., AQUEOUS ACRYLIC RESIN FOR COATING AN ORIGINAL THEOPHYLLINE GRANULATE, Drug development and industrial pharmacy, 21(8), 1995, pp. 879-888
Spherical granules of theophylline, microcrystalline cellulose and lac
tose are prepared in a high speed granulator using an original method.
Successively, the fraction of granules selected is coated with Eudrag
it RS 30D in a fluid bed coating machine using the bottom spray system
and the wurster column. Finally, these granules are compressed into t
ablets of different hardnesses. Dissolution studies reveal a zero orde
r release of theophylline from the coated granules. After compression,
the kinetics is modified but the tablets remain efficient to control
the theophylline release during 8 hours.