STABILITY OF OMEPRAZOLE SOLUTIONS AT VARIOUS PH VALUES AS DETERMINED BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY

Authors
MATHEW M DASGUPTA V BAILEY RE
Citation
M. Mathew et al., STABILITY OF OMEPRAZOLE SOLUTIONS AT VARIOUS PH VALUES AS DETERMINED BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY, Drug development and industrial pharmacy, 21(8), 1995, pp. 965-971
Citations number
1
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Drug development and industrial pharmacy → ACNP
ISSN journal
03639045
Volume
21
Issue
8
Year of publication
1995
Pages
965 - 971
Database
ISI
SICI code
0363-9045(1995)21:8<965:SOOSAV>2.0.ZU;2-V
Abstract
A stability-indicating HPLC assay method for the quantitation of omepr azole has been developed. The developed method was used to study the e ffect of pH on the stability of omeprazole and to quantify the drug in capsules. The excipients present in the capsules did not interfere wi th the assay procedure. The pH-rate profile curve indicated that the m aximum stability was at pH 11. Below pH 7.8, the decomposition was ver y fast. The decomposition constants have a direct relationship with th e H+ concentrations of the solutions.