INSULIN-RESISTANCE RATHER THAN HYPERINSULINEMIA MORE CLOSELY ASSOCIATED WITH ESSENTIAL-HYPERTENSION

In order to clarify which of the two, insulin resistance or hyperinsul inemia, are more contributable to non obese and non diabetic hypertens ion, insulin sensitivity test was performed. By multiple regression an alysis, mean, systolic, and diastolic blood pressure were inversely co rrelated with glucose clearance. During insulin sensitivity test, plas ma catecholamines levels and FENa were not changed by insulin infusion . In the present study, it is demonstrated that insulin has no hyperte nsive effect under the mild hyperinsulinemia (45-55 mu U/ml). We concl ude that insulin resistance rather than hyperinsulinemia may be more c losely associated with non obese and non diabetic hypertension.