Objective: To determine the effect of surgical wound infection on post
operative duration of hospital stay. Design: A case-control study nest
ed within a cohort. Setting: A tertiary-care hospital. Patients: Selec
ted from a cohort of 4702 inpatients who underwent surgical procedures
over a 12-month period. There were 3602 patients, 1100 having been ex
cluded because of lack of infection associated with a particular surgi
cal procedure, because of ''lumping'' of procedures under a nonhomogen
eous heading or because a procedure was unlikely to be the reason for
the patient's hospitalization. Main Outcome Measure: Postoperative dur
ation of hospital stay. Results: In the cohort 89 wound infections wer
e identified, 73 of these occurring with procedures selected for study
. Five patients were excluded from the study because of data deficienc
ies, leaving 68 patients who underwent 15 different procedures. These
were compared with 136 control patients selected by stratified random
sample from a list of patients who underwent the same risk-indexed pro
cedure in the same surgical division. Wound infection patients and con
trols did not differ in anesthetic risk score or procedure duration. P
atients with infection remained in hospital 19.5 days longer than cont
rols (95% confidence interval, range from 11.0 to 27.9 days). Deep-sea
ted infections prolonged the hospital stay more than superficial incis
ional infections (24.3 versus 13.2 days). Conclusions: Surgical wound
infection markedly prolonged the duration of hospitalization in the Un
iversity of Alberta Hospitals, longer than that documented in previous
studies in other countries. Maximizing opportunities to prevent wound
infection would be beneficial to both patients and hospitals.