BAZEX ACROKERATOSIS-PARANEOPLASTICA - TRE ATMENT WITH ACITRETINE

Introduction. Bazex paraneoplastic acrokeratosis remains a therapeutic challenge when the cancer cannot be treated. We report the third pati ent in which a complete clearance of the lesions was obtained with ora l acitretine. Case report. A 67 year-old patient had Bazex paraneoplas tic acrokeratosis. Despite a complete cancer screening, no cancer was found. A cervical lymph node metastasis was treated with surgery and r adiotherapy. Because the cutaneous lesions got worse after this treatm ent, the patient received oral acitretine. A complete clearing of the lesions was observed within 2 months. Discussion. Only 2 similar cases have been reported to our knowledge. The comparison with these 2 case s supports the efficacy of oral retinoids in this disease. The search and the treatment of the cancer remain compulsory. Conclusion. In some definite cases, oral retinoids can be proposed as a treatment of cuta neous lesions in Bazex paraneoplastic acrokeratosis.