POPULATION PHARMACOKINETICS - FUNDAMENTALS, METHODS AND APPLICATIONS

The application of pharmacokinetic principles can maximize the goals o f drug administration from the time a drug is first administered td ma n during the initial phases of development, to well beyond the approva l of the NDA. Population pharmacokinetics is playing an increasing rol e in this regard. This paper provides a comprehensive review of the pr inciples and methods of population pharmacokinetics. Finally, examples of how population pharmacokinetics may be applied to optimize drug ad ministration are presented.