TREATMENT OF DIARRHEA IN CARCINOID-SYNDROME WITH ONDANSETRON, TROPISETRON, AND CLONIDINE

Authors
SCHWORER H MUNKE H STOCKMANN F RAMADORI G
Citation
H. Schworer et al., TREATMENT OF DIARRHEA IN CARCINOID-SYNDROME WITH ONDANSETRON, TROPISETRON, AND CLONIDINE, The American journal of gastroenterology, 90(4), 1995, pp. 645-648
Citations number
37
Categorie Soggetti
Gastroenterology & Hepatology
Journal title
The American journal of gastroenterology → ACNP
ISSN journal
00029270
Volume
90
Issue
4
Year of publication
1995
Pages
645 - 648
Database
ISI
SICI code
0002-9270(1995)90:4<645:TODICW>2.0.ZU;2-Y
Abstract
A 69-yr-old man with known carcinoid syndrome treated with octreotide and interferon-alpha(2b) developed diarrhea, with six to eight watery to semiliquid stools per day. Diminished stool frequency and increased stool consistency were obtained by treatment with the 5-hydroxytrypta mine-3 receptor antagonists ondansetron and tropisetron, Successful al leviation of the diarrhea was also observed with the alpha 2-receptor agonist clonidine, These observations indicate that these classes of d rugs should be evaluated in a controlled trial in patients with carcin oid-associated diarrhea.