Etodolac is a new pyranocarboxylic acid nonsteroidal antiinflammatory
agent with a unique chemical structure indicated for use in patients w
ith painful musculoskeletal disorders and rheumatoid disease. Hepatoto
xicity, in the form of reversible elevations in transaminases or bilir
ubin, occurs rarely. We present the first reported case of fulminant h
epatic failure related to etodolac.