CHIRAL SEPARATION OF SOME 1-AZABICYCLO[3.3.1]NON-3-EN DERIVATIVES ON CHIRALCEL OF STATIONARY-PHASE

Authors
BIDLOIGLOY M ABRAHAM G SOLYOM S MULLER J
Citation
M. Bidloigloy et al., CHIRAL SEPARATION OF SOME 1-AZABICYCLO[3.3.1]NON-3-EN DERIVATIVES ON CHIRALCEL OF STATIONARY-PHASE, ACH, models in chemistry, 131(6), 1994, pp. 819-828
Citations number
8
Categorie Soggetti
Chemistry
Journal title
ACH, models in chemistry → ACNP
ISSN journal
12178969
Volume
131
Issue
6
Year of publication
1994
Pages
819 - 828
Database
ISI
SICI code
1217-8969(1994)131:6<819:CSOS1D>2.0.ZU;2-U
Abstract
Chiral HPLC methods were elaborated for enantiomeric separation of som e 1-aza-bicyclo[3.3.1]non-3-en derivatives of pharmaceutical interest. The aim was to separate (+) and (-) enantiomers of endo and exo isome rs. Chiralcel OF column and the use of hexane/2-propanol mobile phases containing diethyl amine proved to be suitable for chiral resolution. The(+) and (-) enantiomers of the endo and exo structures were succes sfully resolved.