ENDOMETRIAL ESTROGEN AND PROGESTERONE RECEPTORS AND THEIR RELATIONSHIP TO SONOGRAPHIC ENDOMETRIAL APPEARANCE

Citation
Y. Ohno et al., ENDOMETRIAL ESTROGEN AND PROGESTERONE RECEPTORS AND THEIR RELATIONSHIP TO SONOGRAPHIC ENDOMETRIAL APPEARANCE, Human reproduction, 10(3), 1995, pp. 708-711
Citations number
15
Categorie Soggetti
Reproductive Biology
Journal title
ISSN journal
02681161
Volume
10
Issue
3
Year of publication
1995
Pages
708 - 711
Database
ISI
SICI code
0268-1161(1995)10:3<708:EEAPRA>2.0.ZU;2-V
Abstract
The present study was undertaken to evaluate a possible relationship b etween the endometrial concentrations of oestrogen receptor (ER) or pr ogesterone receptor (PR), and the sonographic appearance of human endo metrium. Sonographic assessments and aspirations of the endometrium at the time of or prior to ovulation were made in 48 cycles of 45 infert ile women. Endometrial patterns were classified as A, triple line patt ern, or B, not triple line, on the basis of echogenicity. We did not f ind a correlation between ER or PR and serum oestradiol or endometrial thickness. Furthermore, serum oestradiol concentrations were not corr elated with endometrial pattern or thickness, The only significant cor relations were found between the concentrations of ER and PR in the pa ttern A endometrium (r = 0.80, P < 0.01) and in the pattern B endometr ium (r = 0.49, P < 0.05). There were no differences in the mean concen trations of ER and PR despite differences in endometrial pattern and t hickness, However, PR was measured at >800 fmol/mg protein in 12 out o f 38 pattern A endometria, while PR was <800 fmol/mg protein in all pa ttern B endometria, These data suggest that high PR expression in the pre-ovulatory period is related to an adequate endometrial growth and thereby increases the responsiveness of the endometrium to progesteron e stimulation after ovulation.