Mp. Mingeotleclercq et al., MOLECULAR-PARAMETERS INVOLVED IN AMINOGLYCOSIDE NEPHROTOXICITY, Journal of toxicology and environmental health, 44(3), 1995, pp. 263-300
Aminoglycoside antibiotics are hydrophilic molecules consisting of an
aminated cyclitol associated with amino sugar. They bind in vivo as we
ll in vitro to negatively charged membranes. Their use as chemotherape
utic agents is unfortunately accompanied by oto- and nephrotoxic react
ions, and the purpose of this review is to examine the role oi the mol
ecular interactions between aminoglycosides and membranes in the devel
opment of nephrotoxicity. P-31 Nuclear magnetic resonance (NMR) and fl
uorescence depolarization have been used to characterize the effect oi
aminoglycosides on phosphate heads and fatty acyl chains of phospholi
pids. N-15 NMR has been used to obtain interesting information on