ENANTIOMER SEPARATION OF SMALL AMOUNTS OF AMINO-ACIDS AND HYDROXY-ACIDS BY HPLC USING CHIRAL STATIONARY PHASES AND ACHIRAL DERIVATIZING REAGENTS

Authors
OI N KITAHARA H KISU N
Citation
N. Oi et al., ENANTIOMER SEPARATION OF SMALL AMOUNTS OF AMINO-ACIDS AND HYDROXY-ACIDS BY HPLC USING CHIRAL STATIONARY PHASES AND ACHIRAL DERIVATIZING REAGENTS, Bunseki Kagaku, 44(4), 1995, pp. 301-305
Citations number
9
Categorie Soggetti
Chemistry Analytical
Journal title
Bunseki Kagaku → ACNP
ISSN journal
05251931
Volume
44
Issue
4
Year of publication
1995
Pages
301 - 305
Database
ISI
SICI code
0525-1931(1995)44:4<301:ESOSAO>2.0.ZU;2-H
Abstract
The enantiomer separation of small amounts of amino acids and hydroxy acids by HPLC using chiral stationary phases and achiral derivatizing reagents was examined. Racemic dabsyl amino acids and pyrene-1-carbony l hydroxy acids were well resolved on chiral stationary phases [VI] an d [V], and excellent values of detection limits were obtained. The joi nt use of chiral stationary phases and achiral derivatizing reagents w as found to be very effective for the separation and determination of small amounts of amino acid and hydroxy acid enantiomers by HPLC.