F. Pascal et al., MODELING OF AN INDUSTRIAL ALCOHOL FERMENTATION AND SIMULATION OF THE PLANT BY A PROCESS SIMULATOR, Biotechnology and bioengineering, 46(3), 1995, pp. 202-217
The aim of the present study was the development of a general simulati
on module for fermentation within the framework of existing chemical p
rocess simulators. This module has been applied to an industrial plant
which produces ethanol from beet molasses and fresh beet juice by Sac
charomyces cerevisiae. An unstructured mechanistic model has been deve
loped with kinetic laws that are based on a chemically defined reactio
n scheme which satisfies stoichiometric constraints. This model can be
applied to different culture conditions and takes into account second
ary byproducts such as higher alcohols. These byproducts are of prime
importance and need to be correctly estimated because a sequence of di
stillation columns follow the fermenter in the plant. Important measur
ement campaigns have been performed on the plant to validate the model
. Plant operation has been successfully simulated using the same kinet
ic model for both continuous and fed-batch modes of production. (C) 19
95 John Wiley & Sons, Inc.