ECHOVIRUS-1 INTERACTION WITH THE ISOLATED VLA-2 I-DOMAIN

Authors
KING SL CUNNINGHAM JA FINBERG RW BERGELSON JM
Citation
Sl. King et al., ECHOVIRUS-1 INTERACTION WITH THE ISOLATED VLA-2 I-DOMAIN, Journal of virology, 69(5), 1995, pp. 3237-3239
Citations number
18
Categorie Soggetti
Virology
Journal title
Journal of virology → ACNP
ISSN journal
0022538X
Volume
69
Issue
5
Year of publication
1995
Pages
3237 - 3239
Database
ISI
SICI code
0022-538X(1995)69:5<3237:EIWTIV>2.0.ZU;2-Z
Abstract
The isolated I domain of the integrin VLA-2, produced as a bacterial f usion protein, specifically bound echovirus 1 and prevented virus atta chment to cells. These results demonstrate that the receptor structure s critical for virus attachment are contained solely within the VLA-2 I domain and that soluble receptor fragments are capable of preventing infection.