GLOMERULAR-LESIONS IN CHRONIC LYMPHOPROLIFERATIVE DISORDERS

We studied the association of glomerular diseases with chronic lymphop roliferative disorders and Hodgkin's disease reviewing the literature- and comparing our personal experience. Lymphocytic leukemias are mainl y associated with membranoproliferative glomerulonephritis, whereas gl omerular lesions observed with non-Hodgkin's lymphoma are more heterog eneous. The predominant renal manifestations associated with Hodgkin's disease are amyloidosis and minimal change disease. Underlying pathop hysiology involving specific humoral factors produced by these hematol ogic malignancies is discussed in detail. Finally, we stress the clini cal and therapeutic interest in recognizing such an association, becau se the nephropathy may reveal the hemopathy or accompany a relapse, an d the malignancy treatment is also frequently effective toward the nep hropathy.