PARTICLE-SIZE DETERMINATION BY AUTOMATED MICROSCOPIC IMAGING ANALYSISWITH COMPARISON TO LASER DIFFRACTION

Citation
E. Brewer et A. Ramsland, PARTICLE-SIZE DETERMINATION BY AUTOMATED MICROSCOPIC IMAGING ANALYSISWITH COMPARISON TO LASER DIFFRACTION, Journal of pharmaceutical sciences, 84(4), 1995, pp. 499-501
Citations number
3
Categorie Soggetti
Chemistry,"Pharmacology & Pharmacy
ISSN journal
00223549
Volume
84
Issue
4
Year of publication
1995
Pages
499 - 501
Database
ISI
SICI code
0022-3549(1995)84:4<499:PDBAMI>2.0.ZU;2-D
Abstract
A rapid and precise microscopical analysis technique for the determina tion of particle size distribution has been developed. Particle size d istribution was determined with a Carl Zeiss Axioplan microscope equip ped with a computer-controlled image analysis system. Area and volume measurements were performed on a number of particles and plotted again st Feret's diameter to yield a distribution histogram. This technique was then applied to several compounds of pharmaceutical interest, and the resulting histograms were compared with histograms determined with a laser diffraction instrument. The reproducibility of the microscopi cal determination was good and the agreement between the two determina tions was dependent an the crystalline shape.