EFFECT OF PH ON INJECTION PHLEBITIS

Authors
SIMAMORA P PINSUWAN S ALVAREZ JM MYRDAL PB YALKOWSKY SH
Citation
P. Simamora et al., EFFECT OF PH ON INJECTION PHLEBITIS, Journal of pharmaceutical sciences, 84(4), 1995, pp. 520-522
Citations number
12
Categorie Soggetti
Chemistry,"Pharmacology & Pharmacy
Journal title
Journal of pharmaceutical sciences → ACNP
ISSN journal
00223549
Volume
84
Issue
4
Year of publication
1995
Pages
520 - 522
Database
ISI
SICI code
0022-3549(1995)84:4<520:EOPOIP>2.0.ZU;2-L
Abstract
Formulation pH has been reported to be responsible for the incidence o f phlebitis. In this study, the effect of pH on injection phlebitis is investigated. Buffers of varying pHs were examined for their ability to produce phlebitis in rabbits, Thermal measurements as well as visua l evaluations were used for phlebitis quantitation. The results show t hat formulation pH between 3.0 and 11.0 does not contribute to the inc idence of phlebitis when administered as an iv bolus injection.