HYPOFIBRINOGENEMIA IS THE COMMONEST CONGENITAL FIBRINOGEN ABNORMALITYIN NORTH-INDIA

Congenital abnormalities of fibrinogen are rare disorders and all the cases reported in the literature indicate that the incidence of afibri nogenaemia is much higher than hypofibrinogenaemia. Of the total of 20 cases reported from other parts of India only one was congenital hypo fibrinogenaemia. In contrast, the present study showed eight patients with congenital hypofibrinogenaemia among a total of nine unrelated No rth Indian patients with a fibrinogen abnormality. This disproportiona tely high incidence of hypofibrinogenaemia suggests the existence of a distinct genetic defect in the North Indian population.