HYPOFIBRINOGENEMIA IS THE COMMONEST CONGENITAL FIBRINOGEN ABNORMALITYIN NORTH-INDIA

Citation
Hp. Pati et al., HYPOFIBRINOGENEMIA IS THE COMMONEST CONGENITAL FIBRINOGEN ABNORMALITYIN NORTH-INDIA, Clinical and laboratory haematology, 17(1), 1995, pp. 47-49
Citations number
10
Categorie Soggetti
Hematology
ISSN journal
01419854
Volume
17
Issue
1
Year of publication
1995
Pages
47 - 49
Database
ISI
SICI code
0141-9854(1995)17:1<47:HITCCF>2.0.ZU;2-E
Abstract
Congenital abnormalities of fibrinogen are rare disorders and all the cases reported in the literature indicate that the incidence of afibri nogenaemia is much higher than hypofibrinogenaemia. Of the total of 20 cases reported from other parts of India only one was congenital hypo fibrinogenaemia. In contrast, the present study showed eight patients with congenital hypofibrinogenaemia among a total of nine unrelated No rth Indian patients with a fibrinogen abnormality. This disproportiona tely high incidence of hypofibrinogenaemia suggests the existence of a distinct genetic defect in the North Indian population.