MOLECULAR-IDENTIFICATION OF HEREDITARY PERSISTENCE OF FETAL HEMOGLOBIN TYPE-2 (HPFH TYPE-2) IN PATIENTS FROM BRAZIL

Authors
GONCALVES MS FAHEL S FIGUEIREDO MS KIMURA EJ NECHTMAN F STOMING TA ARRUDA VR SAAD STO COSTA FF
Citation
Ms. Goncalves et al., MOLECULAR-IDENTIFICATION OF HEREDITARY PERSISTENCE OF FETAL HEMOGLOBIN TYPE-2 (HPFH TYPE-2) IN PATIENTS FROM BRAZIL, Annals of hematology, 70(3), 1995, pp. 159-161
Citations number
15
Categorie Soggetti
Hematology
Journal title
Annals of hematology → ACNP
ISSN journal
09395555
Volume
70
Issue
3
Year of publication
1995
Pages
159 - 161
Database
ISI
SICI code
0939-5555(1995)70:3<159:MOHPOF>2.0.ZU;2-J
Abstract
The HPFH deletion type 2 was first described in a patient from Ghana a nd is characterized by a large deletion of approximately 105 kb extens ion. We report here the results obtained in studying a black Brazilian patient who presented an association of beta-thalassemia and HPFH typ e 2, using a PCR strategy for detection of the breakpoint region. This procedure allows a rapid molecular identification of this condition a nd is a reliable procedure for screening patients with a hematological picture of HPFH deletion types.