GASTROINTESTINAL MOTILITY DISORDERS AND BACTERIAL OVERGROWTH

Data on the relationship between small intestinal motility, absorption , and nutrition are sparse and incomplete. Yet, impaired motility is c onsidered to be a plausible cause of bacterial overgrowth, which may h ave deleterious effects on digestion and absorption. This review discu sses the scientific validity and clinical relevance of the concept tha t intestinal motor abnormalities are responsible for enteric bacterial overgrowth. Disorders associated with intestinal dysmotility and bact erial overgrowth, are illuminated, and concurrent studies of intestina l motility and microflora are focused on in detail. Moreover, practica l considerations are given with regard to the clinical management of p atients with bacterial overgrowth. Available data allow the conclusion to be drawn that impaired intestinal motility, as evidenced by attenu ated migrating motor complex activity, results in bacterial overgrowth . The criteria for an intestinal motility disorder likely to result in bacterial overgrowth have been determined in patients with late radia tion enteropathy, but studies in other clinical conditions are needed to establish general guidelines.