DELAYED-HYPERSENSITIVITY REACTION AFTER INFUSION OF NONIONIC INTRAVENOUS CONTRAST MATERIAL FOR AN EXCRETORY UROGRAM - A CASE-REPORT AND REVIEW OF THE LITERATURE

Delayed adverse reactions to ionic and nonionic intravenous contrast m edia have been reported previously. We report a case in which delayed hypersensitivity to iohexol, a nonionic intravenous contrast agent com monly used in excretory urography, resulted in a bi-phasic allergic re sponse. This reaction consisted of a mild post-infusion episode of urt icaria, which preceded and was clinically distinct from a moderately s evere dermatological eruption. The episode of urticaria was self-limit ed. The dermatological reaction was treated successfully with antihist amine therapy.