DISTRIBUTION OF CISPLATIN IN PERILYMPH AND CEREBROSPINAL-FLUID AFTER INTRAVENOUS ADMINISTRATION IN THE GUINEA-PIG

The concentration of free cisplatin was followed in plasma, scala tymp ani perilymph and cerebrospinal fluid (CSF) after an intravenous injec tion (12.5 mg/kg) in guinea pigs. Liquid chromatography with postcolum n derivatization was used for quantitative determination of the drug. The distribution of cisplatin to CSF was fast; at 10 min after drug ad ministration the concentration was 7 mu g/ml and the CSF:plasma ratio was 0.37. Cisplatin seems to distribute more slowly to the perilymphat ic compartment. The highest concentration measured was 4 mu g/ml at 20 min after the injection, and the perilymph:plasma ratio was 0.40 at t hat time. The concentration-time curves generated for cisplatin in per ilymph and CSF were similar. No accumulation in the perilymphatic comp artment or CSF was observed.