ROLES OF RETINOIC ACID RECEPTORS AND OF HOX GENES IN THE PATTERNING OF THE TEETH AND OF THE JAW SKELETON

Authors
MARK M LOHNES D MENDELSOHN C DUPE V VONESCH JL KASTNER P RIJLI F BLOCHZUPAN A CHAMBON P
Citation
M. Mark et al., ROLES OF RETINOIC ACID RECEPTORS AND OF HOX GENES IN THE PATTERNING OF THE TEETH AND OF THE JAW SKELETON, The International journal of developmental biology, 39(1), 1995, pp. 111-121
Citations number
66
Categorie Soggetti
Developmental Biology
Journal title
The International journal of developmental biology → ACNP
ISSN journal
02146282
Volume
39
Issue
1
Year of publication
1995
Pages
111 - 121
Database
ISI
SICI code
0214-6282(1995)39:1<111:RORARA>2.0.ZU;2-7
Abstract
Retinoic acid receptors and transcriptional factors encoded by Hox gen es play key roles in vertebrate development and belong to an integrate d functional network. To investigate the actual functions of these mol ecules during ontogenesis and in particular in the patterning of the c ranial neural crest cells giving rise to the teeth and to the jaw bone s, we have generated null mutant mice lacking functional retinoic acid receptors or Hox genes by gene targeting in embryonic stem cells.