ALCOHOL INHIBITS 11-BETA-HYDROXYSTEROID DEHYDROGENASE-ACTIVITY IN RAT-KIDNEY AND LIVER

Authors
VALENTINO R TOMMASELLI AP SAVASTANO S STEWART PM GHIGGI MR GALLETTI F MARINIELLO P LOMBARDI G EDWARDS CRW
Citation
R. Valentino et al., ALCOHOL INHIBITS 11-BETA-HYDROXYSTEROID DEHYDROGENASE-ACTIVITY IN RAT-KIDNEY AND LIVER, Hormone research, 43(5), 1995, pp. 176-180
Citations number
22
Categorie Soggetti
Endocrynology & Metabolism
Journal title
Hormone research → ACNP
ISSN journal
03010163
Volume
43
Issue
5
Year of publication
1995
Pages
176 - 180
Database
ISI
SICI code
0301-0163(1995)43:5<176:AI1DIR>2.0.ZU;2-O
Abstract
Male Wistar rats were treated with different ethanol concentrations di luted in drinking water in order to evaluate the effect of acute ethan ol intoxication on 11 beta-hydroxysteroid dehydrogenase (11 beta-OHSD) activity in liver and kidney tissue homogenates. Rats with the highes t ethanol, consumption (15% ethanol supplementation) showed a signific ant decrease in both hepatic and renal 11 beta-OHSD activity as compar ed to the control group (p < 0.005). In the same group, aldosterone pl asma levels were significantly lower than in controls (p < 0.01), whil e corticosterone (B) plasma levels were slightly higher, suggesting th at the increase in intrarenal B concentrations, probably related to th e acute ethanol consumption, might be responsible for a nonspecific B mineralocorticoid activity.