TOXICOLOGIC AND ONCOGENIC POTENTIAL OF JP-4 VAPOR - 90-DAY CONTINUOUSINHALATION EXPOSURE

Male and female Fischer 344 rats, female C57BL/6 mice, and male and fe male beagle dogs were divided into three treatment groups and exposed nearly continuously (23 h/day, 7 days/wk) to IP-4 jet fuel vapor at co ncentrations of 0, 500, and 1000 mg/m(3) for 90 days. At exposure term ination, all dogs and one-third of the rodents were euthanized and the remaining animals were held for either a 19- or 21-mo postexposure tu morigenesis observation period. Pathologic findings in male rats revea led treatment-related renal toxicity consistent with male rat alpha(2 mu)-globulin nephropathy. No treatment-related respiratory toxicity wa s noted in any species. This study did not demonstrate target-organ to xicity or carcinogenesis that could be extrapolated to other species.