MONOFLUOROPHOSPHONATES AS PHOSPHATE MIMICS IN BIOORGANIC CHEMISTRY - A COMPARATIVE-STUDY OF CH2-PHOSPHONATE, CHF-PHOSPHONATE AND CF2-PHOSPHONATE ANALOGS OF SN-GLYCEROL-3-PHOSPHATE AS SUBSTRATES FOR SN-GLYCEROL-3-PHOSPHATE DEHYDROGENASE

Authors
NIESCHALK J OHAGAN D
Citation
J. Nieschalk et D. Ohagan, MONOFLUOROPHOSPHONATES AS PHOSPHATE MIMICS IN BIOORGANIC CHEMISTRY - A COMPARATIVE-STUDY OF CH2-PHOSPHONATE, CHF-PHOSPHONATE AND CF2-PHOSPHONATE ANALOGS OF SN-GLYCEROL-3-PHOSPHATE AS SUBSTRATES FOR SN-GLYCEROL-3-PHOSPHATE DEHYDROGENASE, Journal of the Chemical Society, Chemical Communications, (7), 1995, pp. 719-720
Citations number
22
Categorie Soggetti
Chemistry
Journal title
Journal of the Chemical Society, Chemical Communications → ACNP
ISSN journal
00224936
Issue
7
Year of publication
1995
Pages
719 - 720
Database
ISI
SICI code
0022-4936(1995):7<719:MAPMIB>2.0.ZU;2-8
Abstract
The synthesis of the cyclohexylammonium salts of 3-(S),4-dihydroxy-1(R ,S)-fluorobutylphosphonic acid 3 and 1,1-difluoro-3-(S),4-dihydroxybut ylphosphonic acid 4 is reported; 3 is a better substrate for NADH link ed sn-glycerol-3-phosphate dehydrogenase than the difluoromethylenepho sphonate 4; a comparative study of the CH2-, CHF and CF2- phosphonate analogues of sn-glycerol-3-phosphate is reported.