MAPPING OF THE FUNCTIONAL ACTIVE-SITE OF BAEYER-VILLIGERASES BY SUBSTRATE ENGINEERING

Authors
KELLY DR KNOWLES CJ MAHDI JG TAYLOR IN WRIGHT MA
Citation
Dr. Kelly et al., MAPPING OF THE FUNCTIONAL ACTIVE-SITE OF BAEYER-VILLIGERASES BY SUBSTRATE ENGINEERING, Journal of the Chemical Society, Chemical Communications, (7), 1995, pp. 729-730
Citations number
13
Categorie Soggetti
Chemistry
Journal title
Journal of the Chemical Society, Chemical Communications → ACNP
ISSN journal
00224936
Issue
7
Year of publication
1995
Pages
729 - 730
Database
ISI
SICI code
0022-4936(1995):7<729:MOTFAO>2.0.ZU;2-N
Abstract
An active sits model for enzyme catalysed Baeyer-Villiger reactions is proposed and validated by transformation of the tricyclic ketone 6; B aeyer-Villiger reactions (and Baeyer-Villigerases) are classified by t he stereochemistry of the hydroxyperoxide intermediate.