LIVER BIOCHEMICAL PATHOLOGY OF CHOLINE DEFICIENCY AND OF METHYL-GROUPDEFICIENCY - A NEW ORIENTATION AND ASSESSMENT

New information on the pathologic effects of a choline deficient diet in the rat, in relation to the biochemical events, has led to a new un derstanding and orientation of the pathogenesis of both acute and chro nic consequences in the Liver. The biochemical pathology of choline de ficiency is quite different than that of methyl group (lipotrope) defi ciency. These studies in our laboratory and elsewhere are generating n ew insights and hypotheses concerning the genesis of hepatocyte necros is and hepatocellular carcinoma in the rat fed a choline deficient die t.