Js. Zhang et al., IONIZING RADIATION-INDUCED IL-I-ALPHA, IL-6 AND GM-CSF PRODUCTION BY HUMAN LUNG-CANCER CELLS, Chinese medical journal, 107(9), 1994, pp. 653-657
A cell line derived from human lung cancer (AOI) was employed in the p
resent study, A panel of cytokines were quantified by ELISA technique
following cellular exposure to X-irradiation, Tremendous increase in t
he levels of both IL-I alpha and IL-6 were observed, GM-CSF was also d
etected, A comparison of time kinetics of IL-1 alpha and IL-6 producti
on was made with that of cell cycle progression which was determined b
y FCM BrdU/DNA bivariate analysis, No cell cycle specific changes were
found, The biological implication of radiation-induced cytokine produ
ction was discussed.