FACTORS TO CONSIDER IN THE NAMING OF A G-PROTEIN-COUPLED RECEPTOR SUBTYPE

Receptors that mediate their effects through G proteins are predicted to have a seven transmembrane domain architecture. The last few years have seen a remarkable increase in the cloning of members of this supe rfamily leading to the identification of many more receptors than prev iously thought to exist on the basis of differences in agonist and ant agonist specificities. This has important implications for nomenclatur e and classification, especially in view of the difficulty in relating receptors identified through cloning techniques to endogenously expre ssed receptors. Receptor cloning has also identified important differe nces in receptors between species raising the question as to whether t hese should be considered as species homologues or distinct subtypes. It is also becoming increasingly apparent that the pharmacology of thi s superfamily of receptors is influenced by the nature of the G protei n present in the host cell and by alternative splicing of the receptor . The rapid pace of developments in this area necessitate the need for a regular publication summarizing recent developments. In the future, the cloning of G protein-coupled receptors will enable rationalizatio n of the naming of individual receptor subtypes and identification of their interrelationships.