PRODUCTION AND SECRETION OF PROTEINS BY STREPTOMYCETES

Streptomycetes produce a large number of extracellular enzymes as part of their saprophytic mode of life. Their ability to synthesize enzyme s as products of their primary metabolism could lead to the production of many proteins of industrial importance. The development of high-yi elding expression systems for both homologous and heterologous gene pr oducts is of considerable interest. In this article, we review the cur rent knowledge on the various factors that affect the production and s ecretion of proteins by streptomycetes and try to evaluate the suitabi lity of these bacteria for the large-scale production of proteins of i ndustrial importance.