The human gustatory system is capable of responding to and processing
the taste of solitary compounds in water. However, the taste system ra
rely contacts solitary compounds outside the laboratory and has surely
evolved to process complex mixtures of sapid chemicals, such as occur
in virtually all foods. This review will focus primarily on the lesse
r-studied interactions between pairs of salty, sour and bitter compoun
ds. Pair-wise interactions among these three taste qualities should be
of interest because they constitute a significant proportion (similar
to 30-50%) of possible binary taste interactions. In general, salts a
nd acids enhance each other at moderate concentrations but suppress ea
ch other at higher concentrations. Bitter compounds and acids can eith
er enhance or suppress each other depending on the concentrations, the
food stimuli and the experimental methods involved. Sodium salts and
bitter compounds generally interact so that bitterness is suppressed t
o some variable degree and the saltiness is unaffected. As will be des
cribed below, there are exceptions to all of these generalities.