Rare localisations of sarcoidosis, mainly neurological and cardiologic
al ones are in the most cases seriously threatening whether functional
or vital prognosis. They are often responsible for a delay in diagnos
is or treatment. Concerning young patients, any unexplained neurologic
al or cardiological manifestations should lead to consider the diagnos
is of sarcoidosis. When histological evidence is not obtained, in part
icular in presence of central nervous system localisations. Systemic e
xplorations such as pulmonar radiography, bronchoalveolar lavage, sali
var glands biopsies should be performed. In most cases, these localisa
tions will lend to corticotherapy, which, when revealing unsuccessfull
, is associated with another immunosuppressive agent.