FAMILIAL SARCOIDOSIS - 3 CASES IN THE SAM E FAMILY

Familial sarcoidosis is uncommon, representing less than 5% of rile ca ses. We reported three cases of sarcoidosis in the same family (two si sters and a brother) with different clinical presentation in spire of the the presence in each patient of HLA B8 DR3. These HLA phenotype ma y be related with favourable sarcoidosis. Untill the two sisters had a rticula, and benign lymph nodes diseases, the brother had multiviscera l sarcoidosis involving the liver, the lung and the mediastinum. Corti costeroid were used during 6 month with favorable evolution. There is 16 years between tile three sarcoidosis history but the disease appear ed till the third decade. The two sisters and the brother did not live in the same city. These suggest than genetic predisposition is more e ffective than environmental basis.