Sweetener synergy is of vital practical importance to the food manufac
turer but its mechanistic explanation is impossible given the current
limited understanding of sweet taste chemoreception. All current psych
ophysical models of response to sweet stimuli are probably incomplete,
but some fit the experimental data better than others and can thus be
used to predict the taste of sweetener mixtures. Some sweetener mixtu
res have been unequivocally reported as synergistic but such observati
ons do not in themselves constitute evidence for the existence of mult
iple sweet taste receptors, and the interpretation of synergy demands
analysis at the molecular level.