Long referred to as the 'common chemical sense' and frequently describ
ed imprecisely as 'trigeminal sensitivity', chemesthesis provides the
burn of chili pepper, the coolness of menthol and the tingle of carbon
ation. This article is a brief overview of our current understanding o
f the nature of this sensibility, including its relationship to the se
nses of pain and temperature, how it interacts with taste and smell, a
nd why, despite its capacity to produce pungency and pain, it is a pre
valent and desirable attribute of flavor.