CYTOCHROME-P450 IID6 - HIS ACTION IN PSYC HOPHARMACOLOGY

Cytochrome P450 IID6 has got typical features (genetical polymorphism, competitive inhibition, saturability) which cart be at tile origin of pharmacokinetic modifications of molecules using it for their metabol ism. In the field of pharmacology, many molecules are substrates or in hibitors of this cytochrome. They are presented. The results of a stud y of the dextromethorphan variation test performed before and after 28 days of clomipramine therapy with depressed patients are explained. T hey show a significant decreasing of the cytochrome P450 IID6 oxydatio n capacities between both of these times. A patient has passed from th e phenotype <<effective metabolizer>> to the one of <<poor metabolizer >> with clomipramine.