FORMULA-CREATININCLEARANCE AS REPLACEMENT OF 24-HOUR-CREATININCLEARANCE IN CHILDREN AFTER RENAL-TRANSPLANTATION

Despite many theoretical advantages, formula-creatin-inclearance (Schw artz et al, Journal of Pediatrics 1976) has not found broad clinical a cceptance in everyday pediatric patient care. In this study we report our results of long term observations (11,7 +/- 6,8 (1,7-24,8) months) of measured and computed creatininclearance in 27 children after rena l transplantation (15 boys, 12 girls, mean age 14,5 +/- 4,2 (5,5-20) y ears) at the Kinderdialyse of the Universitats-Kinderklinik of Vienna. We found a wide scattered correlation between the measured and comput ed creatininclearance values with a 90% confidence interval between -3 0% to +60% of the 24 hour creatininclearance. Formula creatininclearan ce (SD 17,8%) was markedly better reproducable than the 24 hour creati ninclearancethe (SD 37,8%), the intraindividuell collecting error (36, 1%) was almost twice the interindividuell ,,coefficient'' error (20,27 %). We therefore conclude that the 24 hour creatininclearance is by fa r not as accurate as the complexity of the procedure pretends and supp ort broad clinical acceptance for the formula creatininclearance.