PATHOPHYSIOLOGIC PRINCIPLES RELEVANT FOR THERAPEUTIC PROCEDURES IN PERSISTENT PULMONARY-HYPERTENSION OF THE NEWBORN

Though the various pathophysiologic mechanisms underlying persistent p ulmonary hypertension of the newborn (PPHN) necessitate rather specifi c therapeutic concepts, in the majority of infants with PPHN managemen t is mainly focused on the treatment of the symptoms respiratory failu re and cardiovascular abnormalities. For the few neonates with severe PPHN who fail to respond to optimized conventional ventilatory support , high-frequency oscillatory ventilation and extracorporeal membrane o xygenation are available. Treatment of cardiovascular abnormalities sh ould be based on knowledge of the pathophysiologic events in the heart and in the pulmonary and systemic circulation of the newborn with PPH N at least as far as these events are known or suspected based on anim als Studies. The primary goals of therapy in PPHN must be reduction of right ventricular afterload and support of myocardial function. In th is context inhalational nitric oxide therapy may be effective as a new therapeutic strategy to decrease pulmonary vascular resistance.