GENERATION AND PROPAGATION OF NORMAL AND ABNORMAL PACEMAKER ACTIVITY IN NETWORK MODELS OF CARDIAC SINUS NODE AND ATRIUM

Effects of cell-to-cell coupling conductance on dynamics of sinus node cells are examined. Cell models are biophysically detailed, and are b ased on the kinetic equations developed by Noble ct al. [Neuronal and Cellular Oscillators, edited by J. W. Jacklet. Marcel Deckker, New Yor k (1989).] Resistively coupled cell pairs show five regimes of behavio r as a function of coupling conductance: (1) independent oscillation f or G(c) < 1 pS; (2) primarily quasiperiodic oscillation for 1 less tha n or equal to G(c) < 116 pS; (3) windows of periodic behavior which un dergo period doubling bifurcation to chaos for 116 less than or equal to G(c) < 212 pS; (4) frequency entrainment for G(c) greater than or e qual to 212 pS; (5) waveform entrainment for G(c) greater than or equa l to 50 nS. Thus, only 4-5 gap junction channels are required for freq uency entrainment. This is shown to also be the case for large network s of sinus cells modeled on the Connection Machine CM-5. A biophysical ly detailed two-dimensional network model of the cardiac atrium has al so been implemented on the CM-5 supercomputer. The model is used to st udy effects of spatially localized inhibition of the Na-K pump. Na ove rloading produced by pump inhibition can induce spontaneous, propagati ng ectopic beats within the network. At a cell-to-cell coupling value yielding a realistic plane wave conduction velocity of 60 cms(-1) pump inhibition in small regions of the network containing as few as 1000 cells can induce propagating ectopic beats.