EFFECTS OF 3-(2-ALKOXYPHENYLCARBAMOYLOXY)CHINUCLIDIUM CHLORIDES ON REPAIR-DEFICIENT STRAINS OF CHLAMYDOMONAS-REINHARDTII

The effect of five 3-(2-alkoxyphenylcarbamoyloxy)chinuclidium chloride s (alkoxy = butoxy - octyloxy) on survival of a wild-type strain and r epair-deficient strains of Chlamydomonas reinhardtii was studied. Ther e was a direct relationship with increased toxic effects in the algal strains as a function of the elongation of the alkyl chain of the alko xy substituents of the phenylcarbamate acid derivatives. Repair-defici ent strains were more sensitive than the wild-type strain. The recombi nation-deficient strain uvs 10 expressed the highest sensitivity to th e test agents. This suggests that a gene responsible for recombination repair is involved in an important role in DNA repair of damages indu ced in C. reinhardtii by the phenylcarbamic esters.